University of Arkansas  

Apply Organic Chemistry to Understand Biology

qqqqqqOur research aims to use organic chemistry to understand biological systems, in particular the cell signaling network. We will accomplish this goal by applying concepts and techniques of organic synthesis, medicinal chemistry and chemical genetics. We develop multifunctional chemical probes derived from natural or synthetic glycoconjugates with unique structural and biological properties to unravel novel protein function. Along the way, we will tackle technical challenges in the field of chemical proteomics to effectively identify molecular targets of bioactive small molecules. The ultimate goal of our program is to help develop better chemotherapies for treating/preventing human diseases, especially cancer. To this end, we foster a collaborative learning environment that is conducive to testing new ideas and training the next generation of scientists with multidisciplinary knowledge and skill sets.

Recent News              >> more
May 20, 2017
Yiren Chen joined the group as an undergrad researcher. Welcome, Yiren!
April 19, 2017
Our paper entitled "Design, Synthesis and Biological Evaluation of Fucose-Truncated Monosaccharide Analogues of Ipomoeassin F" has been accepted in the journal of Bioorganic & Medicinal Chemistry Letters. Congratulations Guanghui, Melissa, Collin and Zhijian!
April 19, 2017
Congratulations to Daniel for successfully defending his Honors thesis!
April 14, 2017
Congratulations to Neil for successfully defending his Honors thesis!
April 14, 2017
Congratulations to Carly for successfully defending her Honors thesis!
July 16, 2015
The 'ChemPDP' education and training program is now accetping applications from undergraduate students who are interested in ressearch at the interface of organic chemistry and biology. Check it out!