The Striegler Lab - Research
The Striegler Lab
U of Ark

The Striegler Lab

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Dept. of Chem. & Biochem.
Fulbright College
University of Arkansas
Visitor Information


Dr. Susanne Striegler
Professor
Dept. of Chem. & Biochem.
210 Chemistry Building
University of Arkansas
Fayetteville, AR 72701
U.S.A.
Phone: ++1 (479) 575 5079
FAX: ++1 (479) 575 4049
Email

Last edit: Wednesday, 12-Sep-2012 19:56:09 CDT


Advanced Materials based on Molecular Recognition

 

Our current research efforts are centered on the synthesis and design of functional enzyme models based on molecular recognition between immobilized metal complexes and biomolecules, particularly carbohydrates. We focus on the catalytic synthesis of unnatural sugars that might find use in treating obesity or in enabling an increased oral availability of new glycosylated pharmaceuticals. Noteworthy, the metal complexes involved show carbohydrate differentiation ability, cytotoxicity and antiviral activity that might provide new treatment options for cancer and/or the human immunodeficiency virus (HIV).

Along these lines, we transform transition metal complexes into selective macromolecular catalysts by immobilizing them in templated micro- and nanogels. The material is designed to transform carbohydrates into other, useful entities, such as unnatural sugars and facilitate access to oligosaccharides and new glycosides.


In short, our research efforts focus currently in the following areas:
  • Exploring transition state analogs for glycosidases
  • Developing macromolecular catalysts for selective oligosaccharide synthesis
  • Fighting HIV and cancer with new carbohydrate binding agents
  • Exploring catalysts to access carbohydrates from renewable resources
We use organic synthesis, catalysis, biochemistry and molecular recognition in combination with material science for these interdisciplinary projects. Footer

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Last modified: Wednesday, September 12, 2012 by Webmaster