INTERESTS: Molecular Immunology, Stability of Genes, Control of avian and mammalian immune responses.
RESEARCH I. We have shown that pentoxifylline given during the devlopment of a primary responses enhances the memory responses of T cells. We are currently exploring the mechanism of its activities in lymphocytes. II. We are testing the hypothesis that double stranded breaks accumulate in the DNA in older individuals and that this affects the development of lymphocytes in aged animals.
TEACHING I. Immunology http://www.uark.edu/misc/jdurdik/Immunet/
II. Mechanisms of Pathogenesis
Mattoo H, Kandpal U, Lewis V, Williams M George A, Rath S, Durdik J, Bal V. Naive T cells from aged mice progress poorly to the central memory stage and show increased susceptibility to death upon primary activation . Submitted for publication.
Srivastava S, Banerjee H, Chaudhry A, Khare A, Apurva Sarin A, George A, Bal V, Durdik JM, Rath S. 2007. Apoptosis-inducing factor (Aif) regulates death in peripheral T cells. J. Immunol 179: 797-803.
Vig M, Srviastava S, Kandpal U, Sade H, Lewis V, Sarin A, George A, *Durdik J, *Bal V, *Rath S. 2004. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory. [* communicating authors]. J. Clinical Investigation 113: 1734-1742.
Jena PK, Smith DA, Zhang X, Aviszus K, DurdikJM, Wysocki, LJ 2003.Somatic translocation and differential expression of Ig Mu transgene copies implicate a role for the Igh locus in memory B cell devlopment. Molecular Immunology, 39: 885-897.
Vig M, George A, Sen R, Durdik JM, Rath S, Bal V. Commitment of activated T cells to secondary responsiveness is enhanced by signals mediated through cAMP-dependent protein kinase A-I. 2002 Molecular Pharmacology. 62: 1471-8.
Suresh R*, Vig M*, Bhatia S, Goodspeed EPB, John B, Kandpal U, Srivastava S. George A, Sen R, Bal V+, Durdik JM+, Rath S+. Pentoxifylline functions as an adjuvant in vivo to enhance T cell immune responses by inhibiting activation-induced death. (*joint first authors; +joint corresponding authors). 2002. J. Immunol. 169: 4262-72.
Vandaveer S, Erf G,Durdik J. 2001. Avian Th1/Th2 Immune Response Balance Can Be Shifted Towards Inflammation by Antigen Delivery to Scavenger Receptors. Poultry Science, 80: 172-181.
Morafo V, Thomas M, Rath S, Durdik JM. 1999. Induction of the germinal center phenotype on B cells in vitro by a Th2 cell line. Cellular Immunology 198: 77-86.
Pasare C, Noggle S, Entringer M, Heinzelmann A, Bansal P, George A, Bal V, Rath
S, Durdik JM. 1999. Expression of a recombined immunoglobulin heavy chain
transgene in macrophage as well as lymphocyte lineages in vivo. Eur.
J. Immunol.29: 1219-1227.
Gupta M, George A, Sen R, Rath S, Durdik J, Bal V. 1999. Presence of pentoxifylline during T cell priming increases clonal frequencies in proliferative memory responses and inhibits apoptosis. J. Immunol. 162: 689-695.
Heinzelmann A, Kumar S, Goedegebuur I, Noggle S, Sauer KM, Rath S, Durdik JM. 1998. Deletion of a recombined immunoglobulin heavy chain transgene in B lineage cells of transgenic mice. J. Immunol. 161: 666-673.
Wang W, Durdik JM, Rath S, Sen R. 1998. Pentoxifylline inhibits immunoglobulin kappa gene transcription and rearrangements in pre-B cells. J. Immunol. 160: 1789-1795.
Pasare C, Morafo, V, Entringer, M, Bansal P, George A, Bal V, Rath, S, Durdik JM. 1998. Presence of activated antigen-binding B cells during immunization enhances relative levels of interferon-gamma in T cell responses. J. Immunol. 160: 778-787.
Gupta M, Satyaraj E, Durdik J, Rath S, Bal V. 1997. Differential Regulation of T cell activation for primary versus secondary proliferative responses. J. Immunol. 158: 4113-4121.
Silberstein L, George A, Durdik J, Kipps T. 1996. The V4-34 encoded anti-i autoantibodies recognize a large subset of human and mouse B-cells. Blood Cells, Molecules, and Diseases. 22[13]:126-138.
George A, Rath S, Wang M, Schroff K, and J. M. Durdik. 1994. Crosslinking the CD45 molecule (B220) on B cells can facilitate isotype switching. J. Immunol. 152:1014-1021.